Oral (gavage) two-generation (one litter per generation) reproduction study of perfluorobutane sulfonate (PFBS) in rats | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4289686

Reference Type

Technical Report

Title

Oral (gavage) two-generation (one litter per generation) reproduction study of
perfluorobutane sulfonate (PFBS) in rats

Author(s)

York, RG

Year

2003

Publisher

U.S. Environmental Protection Agency

Location

Washington, D.C.

Report Number

Argus Research Protocol Number 418‐021

Number of Pages

328

Language

English

Relationship(s)

is related to other part(s) 4289697 . Appendix D. Report tables - F1 generation male rats
is related to other part(s) 4289740 . Appendix K. Hisopathology report.

Abstract

On the basis of these data, the maternal no-observable-adverse-effect-level (NOAEL) of PFBS is 300 mg/kg/day (the 100 mg.kg.day dosage caused reductions in body weight gain and rediced absolute and relative feed consumption values). The developmental NOAEL is also 300 mg/kg/day (the 100 mg/kg/day dosage caused reductions in fetal body weights).